Fig. 3
From: Cancer associated fibroblasts in cancer development and therapy
CAFs modulate ECM to promote tumor growth. (A) CAFs promote the deposition of extracellular matrix, forming a physical barrier that hinders immune cell infiltration and drug penetration, thereby creating obstacles for anti-tumor treatment. (B) CAFs remodel ECM, facilitating tumor cell invasion and metastasis. (C) CAFs regulate the balance between dense ECM and loose ECM, thus promoting cancer progression. This figure was created with BioRender.com