Fig. 7
C3G influences the niche function of MKs in a transplant setting. Box plots depict the median and range of (A, C) the percentage of donor (CD45.1+) BM cells, (B, D) total marrow cellularity, (E, F) CD41-expressing BM cells, (G, J) LT-HSC, (H, K) ST-HSC, (I, L) MPP, (M, N) Lin−, (O, P) LKS and (Q, R) LKS− subpopulations of HSPCs in the BM of (A, B, E, G, H, I, M, O, Q) tgC3GPf4 mice or (C, D, F, J, K, L, N, P, R) C3GPf4-KO mice compared to their corresponding wild-type littermates 9 months after transplantation with a 2 × 106-WBM-cell graft. The proportion values in (G–R) were normalized to wtC3GPf4 or C3GPf4-KO, as appropriate. Statistical analyses were performed using t-test. *p ≤ 0.05. Three independent experiments were performed