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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: First-in-human evaluation of memory-like NK cells with an IL-15 super-agonist and CTLA-4 blockade in advanced head and neck cancer

Fig. 5

T cell reconstitution following CIML NK cell infusion. A Distribution of the T cell populations assessed by flow cytometry, mean, and SD. Adjusted p-values for each time point comparison with SRN (trial screening time point) are determined using non parametric anova (Kruskal-Wallis test) followed by Dunn’s multiple comparisons test. B Gene set enrichment analysis of pathways in T cell clusters comparing days + 7 (D7) and + 28 (D28), showing enrichment of pathways of activation at the latter time point. C Gene set enrichment analysis of pathways in T cell clusters comparing IPI untreated (IPI−) and treated (IPI+) conditions. D Expression of exhaustion markers in T cell populations on days + 7 (D7) and + 28 (D28). Boxplots show median and quartiles. Mann-Whitney U test. P-values were calculated per cell type and are detailed in Supplementary Table 15

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