Table 3 Biomarkers and other predictive tools
Predictor molecule | Location | Relationship with prognosis | References |
|---|---|---|---|
FGFR4 | Tissue | Positive correlation | [130] |
miR-3154 | Tissue | Negative correlation | [132] |
Skeletal muscle volume (SMV) | Muscle | Positive correlation | |
KDM6A | Tissue | Positive correlation | [131] |
Neutrophil-to-lymphocyte ratio | Blood | Negative correlation | [124] |
ctDNA | Blood | [133] | |
CD8 + T cell | Blood | Negative correlation | [90] |
C-reactive protein to albumin ratio (CAR) | Blood | Negative correlation | [163] |
Th cell, NK cell | Blood | Positive correlation | [91] |
VEGF、FGF21 和 ANG2 | Serum | Negative correlation | [72] |
Mac-2-binding protein glycosylation isomer (M2BPGi) | Serum | Negative correlation | [166] |
Platelet-lymphocyte ratio(PLR) | Blood | Negative correlation | [164] |
CTL/Treg 比率 | Serum | Positive correlation | [25] |
GALNT14-rs9679162 genotype | Blood | Positive correlation | [170] |
Eosinophil count | Blood | NA | [161] |
ANG2 and VEGF | Serum | VEGF: Positive correlation ANG2: Negative correlation | [165] |
TH1 cell, TNF-α | Blood | Positive correlation | [28] |
CRP | Serum | Negative correlation | [162] |
ST6GAL | Serum | Positive correlation | [167] |
NOS3 rs2070744 genotypes | Blood | [171] | |
2 M-DBR (DBR for the first 60 days), α-fetoprotein and branched-chain Amino acid to tyrosine ratio (BTR) | Blood | Positive correlation | |
Reduction in tumor stain at 2 weeks | Blood, CT | Negative correlation | [172] |
Predictive model/grading | Relationship with prognosis | References |
|---|---|---|
A tumor-to-normal liver ratio (TLR) | Negative correlation | [145] |
Cirrhotic PDX model | [173] | |
Modified albumin-bilirubin grade(mALBI) | Negative correlation | [149] |
Onodera's prognostic nutritional index (O-PNI) | Negative correlation | [155] |
The time-intensity curve (TIC) of arterial phase on contrast-enhanced ultrasound (CEUS) | [141] | |
The albumin-bilirubin (ALBI) grade | Negative correlation | [148] |
Modified Geriatric 8 (mG8) score | Positive correlation | [157] |
The Geriatric Nutritional Risk Index (GNRI) | Positive correlation | [137] |
PIMET score | Positive correlation | [147] |
Blood flow reduction | Positive correlation | [142] |
MPML model | Negative correlation | [158] |
CONUT score | Negative correlation | [156] |
The albumin simplified (ALBS) grade | Negative correlation | [150] |
Glasgow prognostic score (GPS) | Negative correlation | [151] |
AFP-GGT-Hangzhou (AGH) scoring system | Negative correlation | [152] |
Body composition parameters | [139] | |
Prognostic nutrition index (PNI) | Positive correlation | [153] |
Machine learning (ML) radiomics models | [146] | |
Reductions in the rate of mean computed tomography (CT) attenuation values | Negative correlation | [143] |
The lenvatinib prognostic index (LEP) index | Negative correlation | [154] |
A Risk Classifier of South China Cohort (RCOSC) | [159] | |
The computed tomography (CT) attenuation value (CTav) | Positive correlation | [144] |