Prognostic impact of donor mitochondrial genomic variants in myelodysplastic neoplasms after stem-cell transplantation

Table 1 Associations between donor mitochondrial genes and MDS outcomes after allo-HCT

Gene	No. of MDS	No. of Death	No. of Relapse	No. of TRM	OS	RFS	Relapse	TRM
Control region	494	278	178	136	0.02	0.18	0.19	6.44 × 10^− 3*
Complex I	494	278	178	136	0.11	1.21 × 10^− 3*	0.20	0.27
ND1	448	251	162	121	0.29	0.37	0.51	0.17
ND2	483	272	176	131	0.26	0.37	0.02	0.64
ND3	145	91	53	45	0.57	0.33	0.56	0.35
ND4	309	179	108	92	0.14	0.14	0.01	0.08
ND4L	81	46	30	26	0.38	0.93	0.29	0.82
ND5	494	278	178	136	0.44	1.02 × 10^− 4*	6.10 × 10^− 5*	3.60 × 10^− 4*
ND6	190	105	74	47	0.01	0.08	0.28	0.01
Complex III	493	277	177	136	0.08	0.04	9.44 × 10^− 4*	0.69
CYB	493	277	177	136	0.08	0.04	9.44 × 10^− 4*	0.69
Complex IV	402	219	140	109	0.04	0.14	0.43	0.27
CO1	346	194	120	98	0.02	4.06 × 10^− 3	0.01	0.01
CO2	139	66	40	36	0.10	0.19	0.01	0.32
CO3	180	102	67	46	0.15	0.03	0.05	4.86 × 10^− 3
Complex V	491	276	176	136	0.27	0.20	5.12 × 10^− 4*	0.44
ATP6	490	276	176	136	0.34	0.22	2.84	0.55
ATP8	48	30	15	17	0.28	0.36	0.14	0.36
rRNA	489	275	176	135	0.07	0.58	0.04	0.54
tRNA	245	133	88	66	0.08	0.37	0.39	0.08

ISSN: 1756-8722