Table 3 Summary of HSP inhibitors regulating cell death signals in cancer
Name | Structure | Target | Hallmarks of cancer | Cancer cell line | Tumor type | Ref |
|---|---|---|---|---|---|---|
Alvespimycin |
| HSP90 | Induce apoptosis | K562-RD (IC50 = 44 nM) K562-RC (IC50 = 31 nM) | Chronic myeloid leukemia | [141] |
17‑Aminogeldanamycin |
| HSP90 | Induce apoptosis | DMBC12 (0.4 μM) DMBC21 (0.4 μM) DMBC28 (0.4 μM) DMBC29 (0.4 μM) | Melanoma | [142] |
Compound 4f |
| HSP90 | Induce apoptosis | CNE2 (IC50 = 40 nM) | Nasopharyngeal carcinoma | [143] |
Compound 5o |
| GRP94 | Induce apoptosis | HT29 (IC50 = 1.07 ± 0.05 μM) HCT116 (IC50 = 1.88 ± 0.02 μM) SW480 (IC50 = 8.55 ± 0.03 μM) | Colorectal cancer | [144] |
Compound 29 |
| HSP90 | Induce apoptosis | HL-60 (IC50 = 3.69 ± 0.37 μM) | Leukemia | [146] |
Compound 22Â g |
| HSP90 | Induce apoptosis | Hela (IC50 = 19.6 ± 0.4 μM) | Cervical cancer | [148] |
Compound 5b |
| HSP90α | Induce apoptosis | K562 (IC50 = 1.3 ± 0.3 μM) | Leukemia | [149] |
Artesunate |
| HSP70 | Induce apoptosis | 4T1 (IC50 = 52.41 μM) MCF-7 (IC50 = 83.28 μM) | Breast cancer | [155] |
2-phenylethynesulfonamide |
| HSP70 | Induce apoptosis | SCC25 (20 μM) CAL27 (20 μM) | Oral squamous cell carcinoma | [156] |
Compound 6 |
| HSP70 | Induce apoptosis | A2058 (IC50 = 11.62 ± 0.017 μM) | Melanoma | [157] |
CXL146 |
| GRP78 | Induce apoptosis | HL60/MX2 (GI50 = 0.17 ± 0.03 μM) | Leukemia | [158] |
Gefitinib |
| HSP70 | Induce apoptosis | A549 (20 μM) | Lung cancer | [160] |
S1g-6 |
| HSP70 | Induce apoptosis | BV173 (EC50 = 1.4 ± 0.2 μM) KCL22 (EC50 = 2.6 ± 0.4 μM) | Chronic myeloid leukemia | [162] |
Az-TPP-O3 |
| Mortalin | Induce apoptosis | Hela (IC50 = 0.61 ± 0.07 μM) HL60 (IC50 = 0.48 ± 0.06 μM) | Cervical cancer, Leukemia | [163] |
Solasonine |
| Mortalin | Induce apoptosis | HepG2 (IC50 = 4.7 ± 0.2 μM) Hep3b (IC50 = 4.0 ± 0.1 μM) | Hepatocellular carcinoma | [164] |
6-Shogaol |
| HSP60 | Induce apoptosis | A549 (IC50 = 48.67 μM) | Non-small-cell lung cancer | [167] |
Myrtucommulone |
| HSP60 | Induce apoptosis | HL-60 (> 10 μM) | Leukemia | [168] |
J2 |
| HSP27 | Induce apoptosis | SKOV3 (IC50 = 17.34 µM) OVCAR-3 (IC50 = 12.63 µM) | Ovarian cancer | [172] |
Compound 1b |
| HSP105 | Induce apoptosis | Hela (50 μM) | Cervical cancer | [174] |
Gedunin |
| HSP90 | Induce autophagy | A549 (IC50 = 20 µM) | Lung cancer | [182] |
A14 |
| HSP90 | Induce autophagy | A549 (IC50 = 0.1 μM) SK-BR-3 (IC50 = 0.4 μM) | Lung cancer Breast cancer | [183] |
Apoptozole |
| HSP70 | Induce LCD | Hela (IC50 = 5.92 ± 0.47 μM) | Cervical cancer | [163] |
V8 |
| HSP70 | Induce LCD | Hut-102 (6 μM) Jurkat (6 μM) | T cell malignancy | [187] |
