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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing

Fig. 3

SMARCA4 inactivation alters chromatin accessibility in NE-high SCLC. A Heatmap showing ATACseq chromatin accessibility changes (FDR:0.01, FC > 1.5) in H82 and H146 cells after treatment with FHD-286 (100 nM, 14 days). B Enrichment of neuronal and NE HOMER transcription factor-binding DNA motifs in ATAC-seq peaks lost after treatment with FHD-286 (100 nM, 14 days). The percentage indicates the amount of target sequences with motif. C Genomic localization of lost and gained accessible sites upon FHD-286 treatment in H82 and H146 cells. D ATACseq genome tracks of NEUROD1, SYP and CHGA in H82 and H146 cells after treatment with FHD-286. Peaks with a significant reduction in chromatin accessibility are indicated with arrows. E Enrich analysis applied to all genes with lost sites (across all gene body) following FHD-286 treatment. Top 10 GO Biological processes enriched are shown. See also Fig. S4

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Journal of Hematology & Oncology

ISSN: 1756-8722

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