Table 9 Hematologic/myeloid neoplasms with germline predisposition
From: A practical approach on the classifications of myeloid neoplasms and acute leukemia: WHO and ICC
WHO-HAEM5 | ICC | Entities included in both WHO-HAEM5 and ICC | Differences between WHO-HAEM5 and ICC |
|---|---|---|---|
Myeloid neoplasms with germline predisposition without a preexisting platelet disorder or organ dysfunction | Hematologic neoplasms with germline predisposition without a constitutional disorder affecting multiple organ systems | Germline CEBPA, DDX41 and TP53 mutations | None |
Myeloid neoplasms with germline predisposition and pre-existing platelet disorder | Hematologic neoplasms with germline predisposition associated with a constitutional platelet disorder | Germline RUNX1, ANKRD26 and ETV6 mutations | None |
Myeloid neoplasms with germline predisposition and potential organ dysfunction | Hematologic neoplasms with germline predisposition associated with a constitutional disorder affecting multiple organ systems | Germline GATA2 Germline SAMD9/SAMD9L Bone marrow failure syndromes Down syndrome RASopathies (JMML with NF1, CBL) | WHO (not ICC): Germline BLM mutations ICC (not WHO): Diamond-Blackfan anemia |
Not included | Acute lymphoblastic leukemia with germline predisposition | Â | ICC group includes germline PAX5 and IKZF1 mutations. |