Table 11 B lymphoblastic leukemia/lymphoma (B-ALL/LBL)

NOS

Same

with hyperdiploidy

Same

with hypodiploidy

ICC separates this into two subentities:

• low hypodiploid

• near haploid

with iAMP21

Same

with t(9;22)(q34;q11.2); BCR::ABL1

ICC separates this into two subentities:

• with lymphoid only involvement

• with multilineage involvement

BCR::ABL1-like

ICC separates this into three subentities:

• ABL1 class rearranged

• JAK-STAT activated

• NOS

with t(12;21)(p13.2;q22.1); ETV6::RUNX1

Same

ETV6::RUNX1-like*#

Same

with t(1;19)(q23;p13.3); TCF3::PBX1

Same

with t(v;11q23.3); KMT2A rearranged

Same

with t(5;14)(q31.1;q32.1); IGH :: IL3

Same

with HLF rearrangement*

WHO-HAEM5 only lists TCF3::HLF fusion

ICC includes other HLF rearrangements

with DUX4 rearrangement*

Same

with MEF2D rearrangement*

Same

with MYC rearrangement*

Same

with NUTM1 rearrangement*

Same

with PAX5 p.P80R*

Same

with PAX5alt*

Same

with ZNF384 rearrangement*

Same

with UBTF::ATXN7L3/PAN3, CDX2 (“CDX2::UBTF”)*

Only included in ICC, but not WHO-HAEM5

with mutated IKZF1 N159Y*

Only included in ICC, but not WHO-HAEM5

with mutated ZEB2 (p.H1038R)/IGH::CEBPE*

Only included in ICC, but not WHO-HAEM5

ZNF384 rearranged-like*#

Only included in ICC, but not WHO-HAEM5

KMT2A rearranged-like*#

Only included in ICC, but not WHO-HAEM5