Table 3 Comparison of WHO-HAEM4R, ICC and WHO-HAEM5 classification of plasma cell neoplasms and related disorders
WHO HAEM4R | ICC | WHO HAEM5 |
|---|---|---|
Plasma cell neoplasms and related disorders | ||
Monoclonal gammopathies | ||
Not included | Primary cold agglutinin disease | Cold agglutinin disease |
IgM monoclonal gammopathy of uncertain significance (MGUS) | IgM MGUS -Lymphoplasmacytic lymphoma type -Plasma cell neoplasm type Non-IgM MGUS | IgM MGUS Non-IgM MGUS Monoclonal gammopathy of renal significance |
Plasma cell neoplasms | ||
Plasmacytoma -Solitary plasmacytoma of bone -Extraosseous plasmacytoma | -Solitary plasmacytoma of bone -Extraosseous plasmacytoma | Plasmacytoma |
Plasma cell myeloma Plasma cell myeloma variants -Smoldering plasma cell myeloma -Non-secretory myeloma -Plasma cell leukemia | Multiple myeloma (plasma cell myeloma) -Multiple myeloma NOS - Multiple myeloma with recurrent genetic abnormality - Multiple myeloma with CCND family translocation - Multiple myeloma with MAF family translocation - Multiple myeloma with NSD2 family translocation - Multiple myeloma with hyperdiploidy | Plasma cell myeloma/multiple myeloma (PCM/MM) PCM/MM subtypes: -Smoldering plasma cell myeloma -Non-secretory myeloma -Plasma cell leukemia |
Plasma cell neoplasms with associated paraneoplastic syndrome -POEMS syndrome -TEMPI syndrome (provisional) | Plasma cell neoplasms with associated paraneoplastic syndrome -POEMS syndrome -TEMPI syndrome | Plasma cell neoplasms with associated paraneoplastic syndrome -POEMS syndrome -TEMPI syndrome -AESOP syndrome |
Heavy chain diseases | ||
Mu heavy chain disease Gamma heavy chain disease Alpha heavy chain disease | Mu heavy chain disease Gamma heavy chain disease Alpha heavy chain disease | Mu heavy chain disease Gamma heavy chain disease Alpha heavy chain disease |
Diseases with monoclonal immunoglobulin deposition | ||
Primary amyloidosis | -Immunoglobulin light chain amyloidosis (AL) -Localized AL amyloidosis | Immunoglobulin-related amyloidosis (AL amyloidosis) |
Light chain and heavy chain deposition diseases | Light chain and heavy chain deposition disease | Monoclonal immunoglobulin deposition disease |