Fig. 1

A Study profile. B The characteristics of participants. C Results for measurement of plasma methylated OTOP2, KCNA3, or either, in the diagnosis of EC. AUC = The area under the receiver operating characteristic curve. PPV = positive predictive value. NPV = negative predictive value. LR = likelihood ratio. cfDNA = cell-free DNA. EC = esophageal cancer, HGIN = high-grade intraepithelial neoplasia.