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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia

Fig. 1

Neutrophil-specific expression of JAK2-V617F, but not CALRdel, induces thrombocytosis and megakaryocyte hyperplasia. (A-F) White blood cell (WBC) count, neutrophil (NEUT) count, spleen weight, red blood cell (RBC) count, hematocrit, and platelet (PLT) count of Ly6G-Cre JAK2+/+, JAK2+/VF, CALR+/+ and CALR+/del mice (each n = 14). (G) Representative hematoxylin-eosin staining of bone marrow sections of JAK2+/+ (n = 5), JAK2+/VF (n = 3), CALR+/+ (n = 8) and CALR+/del mice (n = 10). (H) Megakaryocyte progenitor (MKP) counts in bone marrow of Ly6G-Cre JAK2+/+ (n = 5), JAK2+/VF (n = 5), CALR+/+ (n = 7) and CALR+/del mice (n = 7) shown as fold change versus control. (I) Quantitative analysis (performed in a blinded fashion) of megakaryocytes (MKs) in bone marrow of Ly6G-Cre JAK2+/+, JAK2+/VF, CALR+/+ and CALR+/del mice in 200x high-power fields (HPF) showing numbers of MKs/HPF as fold change versus control. Data are shown as mean ± SEM. **p ≤ 0.01, ***p ≤ 0.001 (unpaired, two-tailed t-test)

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Journal of Hematology & Oncology

ISSN: 1756-8722

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