Fig. 6

A Chemical structure of METTL3 inhibitor compound 6 and the crystal structure of METTL3/14 in complex with compound 6 (PDB ID: 7ACD). B Design and optimization process of METTL3 inhibitors compound 10 from compound 7 and the crystal structure of METTL3/14 in complex with compound 10 (PDB ID: 7O2F)