Figure 1
From: Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology
miRNA aberrations and hypoacetylated histones drive WM pathogenesis. WM tumor cells present with increased level of miRNA-155, together with increased expression of HDACs and reduced expression of HATs, leading WM clone expansion and tumor progression. (BMSCs: bone marrow stromal cells: miRNA-155: microRNA-155; HDAC: histone deacetylase; HAT: histone acetyltransferase)